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Effects of Ultraviolet Radiation on Glioma: Systematic Review
Savva Pronin1, Chan Hee Koh1, Mark Hughes2
1Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.
Abstract:
Glioblastoma multiforme is the most aggressive primary brain tumor. Treatment is largely palliative, with current strategies unable to prevent inevitable tumor recurrence. Implantable micro-electromechanical systems are becoming more feasible for the management of several human diseases. These systems may have a role in detecting tumor recurrence and delivering localized therapies. One potential therapeutic tool is ultraviolet (UV) light. This systematic review assesses the effects of UV light on glioma cells. A total of 47 publications are included. The large majority were in vitro experiments conducted on human glioblastoma cell lines in monolayer. In these cells, UV light was shown to induce apoptosis and the expression of genes or activation of proteins that modulate cell death, repair, and proliferation. The nature and magnitude of cellular response varied by UV wavelength, dose, cell line, and time after irradiation. UVC (wavelength 100-280 nm) was most effective at inducing apoptosis, and this effect was dose dependent. The included studies had varied methodologies, complicating reconciliation of results. Further work will be required to determine the best regime of UV irradiation for therapeutic use. J. Cell. Biochem. 118: 4063-4071, 2017. © 2017 Wiley Periodicals, Inc.
Insights
Ultraviolet (UV) light shows promise in treating glioblastoma by inducing cancer cell death. Further research is needed to optimize UV therapy for brain tumors.
Area of Science:
- Oncology
- Biophysics
- Molecular Biology
Background:
- Glioblastoma multiforme is an aggressive brain tumor with limited treatment options.
- Tumor recurrence is a significant challenge in glioblastoma management.
- Emerging technologies like micro-electromechanical systems offer potential for localized therapies.
Purpose of the Study:
- To systematically review the effects of ultraviolet (UV) light on glioma cells.
- To assess the potential of UV light as a therapeutic tool for glioblastoma.
Main Methods:
- Systematic review of 47 publications.
- Analysis of in vitro experiments on human glioblastoma cell lines.
- Evaluation of UV light effects based on wavelength, dose, cell line, and time.
Main Results:
- UV light induces apoptosis (programmed cell death) in glioma cells.
- UV irradiation affects genes and proteins involved in cell death, repair, and proliferation.
- UVC light (100-280 nm) demonstrated the most effective apoptosis induction in a dose-dependent manner.
- Cellular responses varied significantly based on experimental parameters.
Conclusions:
- UV light exhibits potential as a therapeutic strategy against glioblastoma.
- The efficacy of UV therapy is dependent on specific parameters like wavelength and dose.
- Further research is required to establish optimal UV irradiation protocols for clinical application.