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Serum macrophage migration inhibitory factor is correlated with atrial fibrillation

Chunfu Wan1, Zhihua Li2

  • 1Department of Pain and Rehabilitation, Forth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.

Journal of Clinical Laboratory Analysis
|April 14, 2017
PubMed
Abstract

Insights

Serum macrophage migration inhibitory factor (MIF) is elevated in atrial fibrillation (AF) patients and correlates with disease severity and left atrial diameter. Higher MIF levels indicate a potential biomarker for AF progression.

Area of Science:

  • Cardiology
  • Immunology
  • Biochemistry

Background:

  • Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine.
  • MIF plays a role in inflammatory processes.
  • The association between MIF and atrial fibrillation (AF) requires further investigation.

Purpose of the Study:

  • To investigate the correlation between serum MIF concentrations and atrial fibrillation (AF).
  • To compare serum MIF levels in AF patients and healthy controls.
  • To explore the relationship between serum MIF and AF subtypes and left atrial diameter.

Main Methods:

  • 186 AF patients and 103 healthy controls were enrolled.
  • AF patients were categorized into paroxysmal, persistent, and permanent AF subgroups.
  • Serum MIF concentrations were measured and analyzed using logistic regression and Spearman correlation.

Main Results:

  • Serum MIF concentrations were significantly higher in AF patients compared to healthy controls.
  • Serum MIF was independently associated with AF.
  • Serum MIF levels increased progressively from paroxysmal to persistent to permanent AF.
  • Elevated serum MIF correlated with increased left atrial diameter.

Conclusions:

  • Serum MIF is a potential biomarker for atrial fibrillation.
  • MIF levels correlate with AF severity and left atrial remodeling.
  • Further research into MIF's role in AF pathogenesis is warranted.
Keywords:
atrial fibrillationinflammationleft atrial diametermacrophage migration inhibitory factor

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