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Potential Applications of Phyto-Derived Ceramides in Improving Epidermal Barrier Function
Efrem N Tessema1, Tsige Gebre-Mariam, Reinhard H H Neubert
1Department of Pharmaceutical Technology and Biopharmaceutics, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Skin Pharmacology and Physiology
|April 14, 2017
Summary
Plant-derived ceramides (phytoCERs) show promise for improving skin hydration and barrier function. This review synthesizes current research on phytoCER oral supplements, highlighting their potential for skin health.
Area of Science:
- Dermatology
- Cosmetic Science
- Biochemistry
Background:
- The stratum corneum's barrier function relies on ceramides (CERs) within its lipid matrix.
- Reduced CER levels are linked to skin conditions like atopic dermatitis, psoriasis, and aged skin.
- Plant-derived ceramides (phytoCERs) offer a safer alternative to synthetic or animal-based CERs.
Purpose of the Study:
- To review the efficacy of phytoCER oral dietary supplements for enhancing skin hydration and barrier function.
- To explore the underlying mechanisms of phytoCERs' beneficial effects on skin health.
- To identify research gaps concerning topical phytoCER applications.
Main Methods:
- Literature review synthesizing existing studies on phytoCERs.
- Analysis of research involving animal models and human subjects.
- Examination of data on oral phytoCER supplementation and skin health.
Main Results:
- PhytoCER-based oral supplements have demonstrated positive effects on skin hydration and barrier reinforcement.
- Studies indicate beneficial outcomes in both animal models and human trials.
- The market offers various ingestible phytoCER supplements.
Conclusions:
- PhytoCERs show significant potential for improving skin barrier function and hydration.
- Further research is needed to explore the cosmetic applications of topically applied phytoCERs.
- This review highlights the importance of plant-derived ceramides for skin health.