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Acral Hemorrhagic Darier Disease

M Á Flores-Terry1, M García-Arpa1, M Llamas-Velasco2

  • 1Servicio de Dermatología, Hospital General Universitario de Ciudad Real, Ciudad Real, España.

Actas Dermo-Sifiliograficas
|April 15, 2017
PubMed

Darier disease is an autosomal-dominant inherited condition caused by mutation of a gene, which produces a protein involved in calcium channel regulation. The disease has a variety of manifestations and lacks consistent genotype-phenotype correlations. Acral hemorrhagic Darier disease causes macules, papules, vesicles and/or hemorrhagic blisters on the extremities. Other classic signs of the disease may be present in the same patient or relatives. Histopathology reveals dyskeratosis and suprabasal acantholysis with hemorrhagic lacunae. We report 3 new cases of this type of Darier disease triggered by injuries. Response to retinoid therapy was good.

Keywords:
Acral hemorrhagic lesionsAcral hemorrágicaDarier diseaseEnfermedad de DarierRetinoidesRetinoids

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