Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acral Hemorrhagic Darier Disease.

M Á Flores-Terry1, M García-Arpa1, M Llamas-Velasco2

  • 1Servicio de Dermatología, Hospital General Universitario de Ciudad Real, Ciudad Real, España.

Actas Dermo-Sifiliograficas
|April 15, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Spot on the Palate.

Actas dermo-sifiliograficas·2026
Same author

Genetic Polymorphisms in Psoriasis: Investigating Genetic Variations for Precise Profiling of Response to Brodalumab in Real-Life Clinical Practice.

Actas dermo-sifiliograficas·2025
Same author

Genetic Polymorphisms in Psoriasis: Investigating Genetic Variations for Precise Profiling of Response to Brodalumab in Real-Life Clinical Practice.

Actas dermo-sifiliograficas·2025
Same author

[Translated article] Facial Discoid Dermatosis. A 13-Case Series.

Actas dermo-sifiliograficas·2025
Same author

Erythematous Papules, Plaques, and Nodules in a Patient With Acute Myeloid Leukemia.

Actas dermo-sifiliograficas·2025
Same author

Facial Discoid Dermatosis. A 13-Case Series.

Actas dermo-sifiliograficas·2025

Darier disease, a genetic disorder affecting calcium channels, can manifest with skin lesions on extremities. This report details three cases of acral hemorrhagic Darier disease triggered by injury, showing good response to retinoid therapy.

Area of Science:

  • Dermatology
  • Genetics
  • Calcium Channel Biology

Background:

  • Darier disease is an inherited condition impacting calcium channel regulation due to gene mutations.
  • It presents with diverse manifestations and inconsistent genotype-phenotype correlations.
  • Acral hemorrhagic Darier disease specifically involves macules, papules, vesicles, or hemorrhagic blisters on extremities.

Observation:

  • This study reports three new cases of acral hemorrhagic Darier disease.
  • The onset of the disease in these cases was triggered by physical injuries.
  • Histopathology confirmed characteristic features like dyskeratosis and suprabasal acantholysis with hemorrhagic lacunae.

Findings:

  • Acral hemorrhagic Darier disease can be precipitated by injuries.
Keywords:
Acral hemorrhagic lesionsAcral hemorrágicaDarier diseaseEnfermedad de DarierRetinoidesRetinoids

Related Experiment Videos

  • The three reported cases demonstrated a positive response to retinoid therapy.
  • This suggests a potential therapeutic avenue for this specific Darier disease subtype.

    • Implications:

    • Understanding injury-induced Darier disease can improve diagnosis and management.
    • Retinoid therapy shows promise for acral hemorrhagic Darier disease.
    • Further research into genotype-phenotype correlations and treatment responses is warranted.