Pharmacokinetics of linezolid during continuous hemodiafiltration: A case report

The pharmacokinetics of linezolid clearance (CL_LZD) during continuous hemodiafiltration (CHDF) has not been comprehensively analyzed. Here, we examined CL_LZD by CHDF in a patient with septic shock and disseminated intravascular coagulation due to methicillin-resistant Staphylococcus aureus. The extraction ratio of LZD by CHDF was 22.6%, and the protein-binding rate was 17.9% ± 7.7%. In addition, it was determined that the calculated total body clearance of LZD was 30.2 mL/min, plasma elimination half-life was 8.66 h, and the CL_LZD by the dialyzer used for CHDF was 23.0 mL/min. From the obtained pharmacokinetics, the CL_LZD of patients continuing CHDF was estimated to be approximately half of the reported CL_LZD for healthy subjects. In addition, the LZD concentration of the sepsis patient who underwent CHDF remained higher than the minimum inhibitory concentration and was similar to the LZD concentrations reported in normal renal function patients. Although further studies are warranted, when LZD is administered to patients treated with CHDF, the present findings suggest that dose regulation is not required.