Using Next-Generation Sequencing to Explore Genetics and Race in the High School Classroom

Area of Science:

• Genetics and Bioinformatics Education
• Personal Genomics Applications
• Science Education Research

Background:

• Personal genomics is increasingly relevant due to advances in sequencing and bioinformatics.
• Engaging high school students in these complex topics requires innovative teaching methods.
• Traditional curricula may not adequately cover modern genetic technologies.

Purpose of the Study:

• To develop and implement a laboratory-based teaching module for high school students.
• To enhance student understanding of sequencing and bioinformatics using the topic of race.
• To evaluate the module's impact on student knowledge and attitudes toward scientific research.

Main Methods:

• Students performed mitochondrial DNA isolation using standard biotechnology techniques.
• Next-generation sequencing data was collected and analyzed by students.
• Pretest/posttest evaluations and surveys assessed learning gains and attitudes.

Main Results:

• Students demonstrated significant learning gains in sequencing and bioinformatics knowledge.
• Lower-performing students showed the most substantial improvements in understanding.
• Student attitudes toward scientific research became more positive after module completion.

Conclusions:

• The "Genetics of Race" module effectively enhances high school students' comprehension of personal genomics.
• Laboratory-based, inquiry-driven learning can significantly improve science education outcomes.
• Integrating relevant social topics can increase student engagement and positive attitudes in STEM fields.