Predictive values of D-dimer assay, GRACE scores and TIMI scores for adverse outcome in patients with non-ST-segment...

Area of Science:

• Cardiology
• Biomarkers
• Risk Stratification

Background:

• Non-ST-segment elevation myocardial infarction (NSTEMI) is a critical cardiovascular condition.
• Accurate risk stratification is essential for managing NSTEMI patients and improving outcomes.
• Existing risk scores and biomarkers require validation for their predictive capabilities in NSTEMI.

Purpose of the Study:

• To evaluate the predictive performance of D-dimer assay, Global Registry of Acute Coronary Events (GRACE) risk score, and Thrombolysis in Myocardial Infarction (TIMI) risk score for adverse outcomes in NSTEMI patients.
• To identify independent predictors of mortality in NSTEMI.

Main Methods:

• A cohort of 234 NSTEMI patients was analyzed.
• Data collected included D-dimer levels, GRACE scores, and TIMI scores.
• Logistic regression analysis was employed to determine mortality predictors.

Main Results:

• Higher serum creatinine levels were the only significant independent predictor of increased mortality (OR=18.465, P=0.046).
• D-dimer assay, GRACE score, and TIMI score showed no significant predictive value for mortality in this NSTEMI cohort.
• GRACE scores positively correlated with D-dimer (r=0.215, P=0.01) and TIMI scores (r=0.504, P=0.000).

Conclusions:

• Serum creatinine is the sole independent determinant of mortality risk in NSTEMI patients.
• D-dimer assay, GRACE, and TIMI risk scores lack significant predictive value for mortality in this population.
• Clinical practice should consider serum creatinine as a key factor in NSTEMI risk assessment.