Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autophagy and the Cell Cycle: A Complex Landscape.

Søs Grønbæk Mathiassen1, Daniela De Zio1, Francesco Cecconi1,2,3

  • 1Cell Stress and Survival Unit, Danish Cancer Society Research Center, Copenhagen, Denmark.

Frontiers in Oncology
|April 15, 2017
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ubiquitin-dependent degradation of p27Kip1 and p21Waf1/Cip1 by AMBRA1 ensures G1 and S phase progression and limits replication stress.

Nucleic acids research·2026
Same author

Purinosomes and mitochondria: Dynamic interactomes at the crossroads of metabolism, cell structure, and disease.

Pharmacological research·2026
Same author

The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis.

Science advances·2025
Same author

ADSL deficiency is a secondary mitochondrial disease affecting organelle homeostasis and ERK2/AKT signaling in a linear genotype-phenotype relation.

Cell reports·2025
Same author

Medulloblastoma: Molecular Targets and Innovative Theranostic Approaches.

Pharmaceutics·2025
Same author

Chemogenetic induction of CA1 hyperexcitability triggers indistinguishable autistic traits in asymptomatic mice differing in Ambra1 expression and sex.

Translational psychiatry·2025

Autophagy, a cellular degradation process, is increasingly linked to cell cycle control and cancer development. Understanding this connection is crucial for cancer research and therapy.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Oncology

Background:

  • Autophagy is a fundamental cellular process for degrading cytoplasmic components via the lysosome, crucial for maintaining cellular homeostasis.
  • While typically cytoprotective under stress, autophagy's role in cancer is complex, sometimes promoting tumor growth.
  • Emerging evidence highlights connections between autophagy, stress responses, and cell division.

Purpose of the Study:

  • To review the reciprocal regulation between the autophagy pathway and cell-cycle progression.
  • To explore the non-canonical functions of autophagy-related factors in cell-cycle control.
  • To elucidate the intricate relationship between autophagy and cancer.

Main Methods:

  • Literature review of recent advances in autophagy and cell-cycle research.
Keywords:
autophagycancercell cyclecell stresscytokinesismitosisp53senescence

Related Experiment Videos

  • Analysis of studies investigating autophagy factors in cell division.
  • Synthesis of findings on the dual role of autophagy in cancer.

    • Main Results:

    • Autophagy and cell-cycle progression are intricately interconnected through reciprocal regulatory mechanisms.
    • Autophagy-related proteins have non-degradative roles in regulating cell division.
    • The role of autophagy in cancer is context-dependent, influencing both tumor suppression and progression.

    Conclusions:

    • The interplay between autophagy and the cell cycle is a critical area for understanding cancer biology.
    • Targeting autophagy pathways presents potential therapeutic strategies for cancer treatment.
    • Further research into the non-canonical functions of autophagy factors may reveal new avenues for cancer intervention.