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Pathogen-associated regulatory non-coding RNAs and oncogenesis.

Noriyuki Yoshida¹, Tominori Kimura²

¹Laboratory of Microbiology and Cell Biology, Department of Pharmacy, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, Shiga 525-8577, Japan.

Frontiers in Bioscience (Landmark Edition)

|April 15, 2017

Summary

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Infectious agents like Helicobacter pylori and oncoviruses cause 15.4% of cancers. Their non-coding RNAs play key roles in oncogenesis, driving cancer development through various mechanisms.

Area of Science:

Oncology
Virology
Molecular Biology

Background:

Infectious agents, including Helicobacter pylori and oncoviruses, are linked to a significant proportion of human cancers.
These pathogens encode non-coding RNAs that are increasingly recognized as critical cofactors in cancer development.

Purpose of the Study:

To review recent advancements in understanding the role of non-coding RNAs from oncogenic pathogens.
To elucidate the mechanisms by which these non-coding RNAs contribute to oncogenesis.

Main Methods:

Literature review focusing on long non-coding RNAs and small non-coding RNAs (including microRNAs) from oncogenic viruses and bacteria.
Analysis of molecular mechanisms underlying pathogen-driven oncogenesis.

Main Results:

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Oncogenic pathogens encode diverse non-coding RNAs that modulate host cell processes.
These non-coding RNAs are implicated in multiple stages of cancer development, from initiation to progression.

Conclusions:

Non-coding RNAs from infectious agents are crucial players in oncogenesis.
Targeting these pathogen-derived non-coding RNAs may offer novel therapeutic strategies for virus-associated cancers.