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Fungal immunomodulatory proteins in the context of biomedicine
Paula Tatiana Uribe-Echeverry1, German Ariel Lopez-Gartner2
1Health Faculty, University of Manizales, Street 9a # 19-03, Manizales, Colombia.
Abstract:
Fungi represent a large group of biodiverse microorganisms with potential applications ranging from industrial fields to the treatment for human diseases. A large number of pharmacologically active compounds including terpenoids, polysaccharides and proteins have been derived from these microorganisms. Fungal Immunomodulatory Proteins (FIPs) are a group of active compounds that are being considered for the treatment of asthma, allergy, autoimmune diseases and cancer. Here, we discuss the discovery, heterologous production bioactive mechanisms of action and their potential use in biomedicine.
Insights
Fungi yield bioactive compounds like Fungal Immunomodulatory Proteins (FIPs) for treating diseases. This review covers FIP discovery, production, mechanisms, and biomedical potential.
Area of Science:
- Mycology and Biotechnology
- Immunology and Pharmacology
Background:
- Fungi are a biodiverse microbial group with significant biotechnological and medicinal applications.
- Pharmacologically active compounds, including terpenoids, polysaccharides, and proteins, are derived from fungi.
- Fungal Immunomodulatory Proteins (FIPs) are a class of proteins with therapeutic potential.
Purpose of the Study:
- To review the discovery and heterologous production of Fungal Immunomodulatory Proteins (FIPs).
- To discuss the bioactive mechanisms of action of FIPs.
- To explore the potential applications of FIPs in biomedicine, including the treatment of asthma, allergy, autoimmune diseases, and cancer.
Main Methods:
- Literature review on FIPs.
- Analysis of FIP discovery and production methodologies.
- Examination of studies on FIP mechanisms and therapeutic efficacy.
Main Results:
- FIPs have been successfully discovered and their production is being optimized through heterologous systems.
- FIPs exhibit diverse immunomodulatory activities through various molecular pathways.
- Preclinical and clinical studies suggest FIPs' potential in managing inflammatory and autoimmune conditions and cancer.
Conclusions:
- Fungal Immunomodulatory Proteins (FIPs) represent a promising class of therapeutic agents derived from fungi.
- Further research into FIPs' production and mechanisms can unlock their full biomedical potential.
- FIPs offer a novel strategy for treating immune-related diseases and cancer.