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Updated: May 1, 2026

Engineering Adherent Bacteria by Creating a Single Synthetic Curli Operon
Published on: November 16, 2012
Engineered microbial biosensors based on bacterial two-component systems as synthetic biotechnology platforms in
Sambandam Ravikumar1, Mary Grace Baylon2, Si Jae Park3
1Biomolecules Engineering Lab, Department of Biotechnology and Bioengineering, Chonnam National University, 77 Yongbong-ro, Gwangju, 61186, Republic of Korea.
Abstract:
Two-component regulatory systems (TCRSs) mediate cellular response by coupling sensing and regulatory mechanisms. TCRSs are comprised of a histidine kinase (HK), which serves as a sensor, and a response regulator, which regulates expression of the effector gene after being phosphorylated by HK. Using these attributes, bacterial TCRSs can be engineered to design microbial systems for different applications. This review focuses on the current advances in TCRS-based biosensors and on the design of microbial systems for bioremediation and their potential application in biorefinery.
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