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Allostery modulates the beat rate of a cardiac pacemaker
Chung-Jung Tsai1, Ruth Nussinov2,3
1From the Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702 and.
The Journal of Biological Chemistry
|April 16, 2017
Abstract
None:
The S672R mutation in heart cell ion channels leads to low heart rates and arrhythmia by an unknown route. A multifaceted NMR analysis now demonstrates that this mutant impacts allosteric coupling in domains inside of the cell to change channel activation, providing a mechanistic explanation for phenotypic outcomes.