Armand R J Girbes1, Paul E Marik2
1Department of Intensive Care, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands. a.girbes@planet.nl.
Evidence-based protocols can aid clinical trials, but bundling unproven elements with standard practices is discouraged. Implementing entire protocol bundles without critical evaluation may hinder optimal patient care.
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