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Glucocorticoids Inhibit Wound Healing: Novel Mechanism of Action
Andrzej T Slominski1, Michal A Zmijewski2
1Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA; Comprehensive Cancer Center, Cancer Chemoprevention Program and Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA; VA Medical Center, Birmingham, Alabama, USA.
Abstract:
Jozic et al. describe mechanisms of glucocorticoid (GC) downregulation of wound healing by interaction with the membrane bound GC receptor, followed by stimulation of β-catenin and c-myc pathways. Targeting the membrane bound GC receptor or the recently discovered interaction of GC with mineralocorticoid receptors may counteract negative effects of GC on the skin barrier and potentially could serve as a remedy for age-related skin atrophy.