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microRNAs as cancer therapeutics: A step closer to clinical application
Tina Catela Ivkovic1, Gjendine Voss2, Helena Cornella2
1Department of Laboratory Medicine, Division of Translational Cancer Research, Lund University, Lund, Sweden; Division of Molecular Medicine, Laboratory for Personalized Medicine, Ruder Boskovic Institute, Zagreb, Croatia.
Abstract:
During the last decades, basic and translational research has enabled great improvements in the clinical management of cancer. However, scarcity of complete remission and many drug-induced toxicities are still a major problem in the clinics. Recently, microRNAs (miRNAs) have emerged as promising therapeutic targets due to their involvement in cancer development and progression. Their extraordinary regulatory potential, which enables regulation of entire signalling networks within the cells, makes them an interesting tool for the development of cancer therapeutics. In this review we will focus on miRNAs with experimentally proven therapeutic potential, and discuss recent advances in the technical development and clinical evaluation of miRNA-based therapeutic agents.
Insights
MicroRNAs (miRNAs) show therapeutic promise for cancer, regulating cellular signaling networks. This review covers their potential and advances in developing miRNA-based cancer therapeutics.
Area of Science:
- Oncology
- Molecular Biology
- Biotechnology
Background:
- Cancer treatment advances have been made, but complete remission and drug toxicity remain significant clinical challenges.
- MicroRNAs (miRNAs) are key regulators of cellular signaling pathways implicated in cancer development and progression.
- The regulatory capacity of miRNAs presents a novel avenue for developing targeted cancer therapeutics.
Purpose of the Study:
- To review microRNAs (miRNAs) with experimentally validated therapeutic potential in cancer.
- To discuss recent advancements in the technical development of miRNA-based therapeutic agents.
- To examine the clinical evaluation of miRNA-based cancer therapies.
Main Methods:
- Literature review of basic and translational research on microRNAs in cancer.
- Focus on miRNAs with experimentally proven therapeutic efficacy.
- Analysis of technical developments and clinical trial data for miRNA therapeutics.
Main Results:
- MicroRNAs demonstrate significant potential as therapeutic targets due to their role in cancer.
- Advances in delivery systems and stability have improved the feasibility of miRNA-based therapies.
- Early clinical evaluations show promise, but further research is needed.
Conclusions:
- MicroRNAs offer a promising strategy to overcome limitations in current cancer treatment, such as incomplete remission and toxicity.
- Continued research and development in miRNA-based therapeutics are crucial for clinical translation.
- miRNA-based agents represent a novel frontier in the fight against cancer.