Aquaporins as potential drought tolerance inducing proteins: Towards instigating stress tolerance

Aquaporins (AQPs) are primarily involved in maintaining cellular water homeostasis. Their role in diverse physiological processes has fascinated plant scientists for more than a decade, particularly concerning abiotic stresses. Increasing examples of evidence in various crop plants indicate that the AQPs are responsible for precise regulation of water movement and consequently play a crucial role in the drought stress tolerance. Since drought is one of the major abiotic stresses affecting agricultural production worldwide, it has become a critical agenda to focus research on the development of drought tolerant crop plants. AQPs can act as key candidate molecules to confront this issue. Hence, there is an important need to explore the potential of AQPs by understanding the molecular mechanisms and pathways through which they induce drought tolerance. Moreover, the signalling network/s involved in such pathways needs to be mined and understood correctly, and that may lead to the development of drought tolerance in crop plants. In the present review, opportunity and challenges regarding the efficient utilization of AQP-related information is presented and discussed. The complied information and the discussion will be helpful for designing future experiments and to set the specific goals for the enhancement of drought tolerance in crop plants. Biological Significance Knowledge on the role of AQPs in maintaining cellular water homeostasis has given new hope for developing drought tolerance in crop plants. Since drought is one of the major abiotic stresses affecting agricultural production worldwide, it has become a critical agenda to focus research on the development of drought-tolerant crop plants. AQPs can act as key candidate molecules to solve this problem through genetic engineering. For this, it is important to understand the molecular mechanisms and inter-related pathways through which AQPs induce drought tolerance and to explore the signaling network/s involved in such pathways.