Related Experiment Video
Updated: Aug 13, 2026

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue
Published on: October 26, 2014
Interictal ripples nested in epileptiform discharge help to identify the epileptogenic zone in neocortical epilepsy
Shuang Wang1, Norman K So2, Bo Jin3
1Department of Neurology, Epilepsy Center, Second Affiliated Hospital, Zhejiang University, Hangzhou, China; Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
Objective:
This study aimed to identify the subtype of interictal ripples that help delineate the epileptogenic zone in neocortical epilepsy.
Methods:
Totally 25 patients with focal neocortical epilepsy who had invasive electroencephalography (EEG) evaluation and subsequent surgery were included. They were followed up for at least 2years. Interictal ripples (80-250Hz) and fast ripples (250-500Hz) during slow-wave sleep were identified. Neocortical ripples were defined as type I ripples when they were superimposed on epileptiform discharges, and as type II ripples when they occurred independently. Resection ratio was calculated to present the extent to which the cortical area showing an interictal event or the seizure onset zone (SOZ) was completely removed.
Results:
Fast ripples and types I and II ripples were found in 8, 19, and 21 patients, respectively. Only the higher resection ratio of interictal fast or type I ripples was correlated to the Engel 1a surgical outcome.
Conclusions:
Type I ripples could assist in localizing the epileptogenic zone in neocortical epilepsy.
Significance:
Type I and fast ripples both may be pathological high-frequency oscillations.
More Related Videos
10:22Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
Published on: December 6, 2016
10:05A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures
Published on: March 18, 2021
Related Concept Videos
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Seizures l: Introduction
Epilepsy ll: Types