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Compounds with inhibitory activity on peristalsis from the seeds of Holarrhena antidysenterica
Hai-Hua Xie1, Jian Su1, Xiao-Lei Ge1
1a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang , People's Republic of China.
Abstract:
Eight compounds were isolated from the seeds of Holarrhena antidysenterica Wall.ex A.DC. On the basis of physico-chemical properties and spectroscopic data, holarrhenanan (1) was identified as a new compound, compounds 2-3 were isolated from H. antidysenterica for the first time, and five known compounds were also obtained. Inhibitory effects of some compounds and extracts to the intestinal peristalsis were evaluated. Results showed that the extracts and compounds 4, 6 exhibited remarkable inhibitory effects with tension inhibition rate of 32.77, 32.77% and amplitude inhibition rate of 59.51, 55.98%, respectively on the vitro rabbit intestinal peristalsis.