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Toll-like receptor 2 gene polymorphisms in Chinese Holstein cattle and their associations with bovine tuberculosis
Zhanqin Zhao1, Yun Xue2, Zhigang Hu2
1Lab of Veterinary Microbiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China; Lab of Medical Engineering, College of Medical Technology and Engineering, Henan University of Science and Technology, No. 31 Anhui Road, Luoyang 471003, China.
Abstract:
This study evaluated whether there was an association between polymorphisms within the Toll-like receptor 2 gene (TLR2) of Chinese Holstein cattle and susceptibility to bovine tuberculosis (BTB). In a case-control study including 210 BTB cases and 237 control cattle, we found only two common single-nucleotide polymorphisms (SNPs) within the entire coding region of the TLR2 gene, A631G (rs95214857) and T1707C (rs1388116488). Additionally, the allele and genotype distributions of A631G and T1707C were not different between case and control groups, indicated that these SNPs were not associated with susceptibility to BTB. These results suggested that polymorphisms in the TLR2 gene might not play a significant role in the BTB risk in Chinese Holstein cattle.