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Related Experiment Videos

The molecular cues regulating immune cell trafficking.

Akira Takeda1, Naoko Sasaki2, Masayuki Miyasaka1,3

  • 1MediCity Research Laboratory, University of Turku.

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
|April 18, 2017
PubMed
Summary

Immune cell trafficking, crucial for immune responses, involves lymphocytes moving between blood and tissues. This review highlights molecular mechanisms governing cell migration, particularly in non-lymphoid tissues.

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Area of Science:

  • Immunology
  • Cell Biology
  • Physiology

Background:

  • Lymphocyte recirculation is vital for immune surveillance and response regulation.
  • This process involves immune cell migration between blood and lymphoid/non-lymphoid tissues.
  • High endothelial venules (HEVs) facilitate lymphocyte trafficking in lymphoid organs, while mechanisms in non-lymphoid tissues are less understood.

Purpose of the Study:

  • To review recent findings on molecular mechanisms of immune cell trafficking.
  • To elucidate the roles of chemokines and lysophospholipids in immune cell migration and endothelial permeability.

Main Methods:

  • Literature review of recent research on immune cell trafficking.
  • Focus on molecular mechanisms governing lymphocyte migration across different vasculature.

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Main Results:

  • Lymphocyte migration across HEVs involves specific adhesion and transmigration steps.
  • Chemokines and lysophospholipids are key regulators of immune cell motility and endothelial barrier function.
  • Understanding migration across non-lymphoid tissue venules is an active area of research.

Conclusions:

  • Molecular mechanisms involving chemokines and lysophospholipids are critical for immune cell trafficking.
  • Further research is needed to fully understand immune cell migration in non-lymphoid tissues.