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Fluorinated polyurethane scaffolds for 19F magnetic resonance imaging
Twan Lammers1,2, Marianne E Mertens1, Philipp Schuster3
1Institute for Experimental Molecular Imaging, RWTH Aachen University Clinic, Pauwelsstrasse 30, 52074 Aachen, Germany.
Chemistry of Materials : a Publication of the American Chemical Society
|April 18, 2017
Summary
New fluorinated polymers enable clear imaging of vascular grafts using 19F MRI. This advancement aids in precise placement and monitoring of tissue-engineered vascular grafts, reducing complications like restenosis.
Area of Science:
- Biomaterials Science
- Medical Imaging
- Polymer Chemistry
Background:
- Polymers are widely used in medical implants, but complications like incorrect placement and restenosis necessitate improved materials.
- Current imaging techniques for vascular grafts have limitations in guiding implantation and postoperative monitoring.
Purpose of the Study:
- To develop novel polymer materials for vascular grafts that facilitate image-guided implantation and accurate postoperative imaging.
- To explore the utility of amorphous fluorinated polymers based on thermoplastic polyurethane (19F-TPU) for enhanced vascular graft visualization.
Main Methods:
- Synthesis of amorphous fluorinated polymers based on thermoplastic polyurethane (19F-TPU).
- Evaluation of 19F-TPU material properties for biocompatibility and imaging potential.
- Demonstration of 19F MRI detectability of 19F-TPU based vascular grafts.
Main Results:
- Successfully synthesized amorphous fluorinated polymers (19F-TPU).
- 19F-TPU materials show promise as suitable starting materials for tissue-engineered vascular grafts.
- The developed grafts are detectable using 19F MRI, enabling clear imaging.
Conclusions:
- Amorphous fluorinated polymers (19F-TPU) are effective for creating vascular grafts with enhanced imaging capabilities.
- 19F MRI allows for accurate detection and monitoring of these novel vascular grafts.
- This technology has the potential to reduce complications associated with vascular graft implantation and improve patient outcomes.