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Type A oncornavirus-like particles in turkey bone marrow cells transformed by avian leukemia virus

E E Shikova1, I G Ivanov, Z M Mladenov

  • 1Institute of General and Comparative Pathology, Bulgarian Academy of Sciences, Sofia, Bulgaria.

Journal of Ultrastructure and Molecular Structure Research
|March 1, 1988
PubMed

Insights

Type A oncornavirus-like particles (TAOLP) were identified in turkey cells infected with avian leukemia virus. These particles may be a byproduct of virus replication, particularly in cells showing damage.

Area of Science:

  • Virology
  • Cell Biology
  • Oncology

Background:

  • Avian leukemia virus (ALV) is a significant pathogen in poultry.
  • Understanding virus replication mechanisms is crucial for disease control.

Purpose of the Study:

  • To investigate the nature and origin of Type A oncornavirus-like particles (TAOLP) observed in avian leukemia virus-infected cells.
  • To explore the potential relationship between TAOLP and the Mc-31 strain of ALV.

Main Methods:

  • Electron microscopy was used to examine turkey bone marrow cells transformed by Mc-31 ALV.
  • Morphological comparison of TAOLP with viral structures.

Main Results:

  • TAOLP were found in the cytoplasm of turkey bone marrow cells infected with Mc-31 ALV.
  • TAOLP resembled the cores of budding and immature Mc-31 virions.
  • TAOLP were more prevalent in cells exhibiting cytopathological changes.
  • TAOLP were not detected in in vivo samples.

Conclusions:

  • A likely relationship exists between TAOLP and Mc-31 ALV.
  • TAOLP may represent a byproduct of Mc-31 ALV replication.

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