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Related Experiment Videos

Circulating ACE2 in Cardiovascular and Kidney Diseases.

L Anguiano1, M Riera1, J Pascual1

  • 1IMIM (Hospital del Mar Medical Research Institute), Barcelona. Spain.

Current Medicinal Chemistry
|April 18, 2017
PubMed
Summary

Circulating Angiotensin converting enzyme (ACE) 2 is elevated in kidney disease patients and associated with cardiovascular risks. This review explores ACE2

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Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Angiotensin converting enzyme (ACE) 2 (ACE2) counterbalances Angiotensin II effects, offering protective cardiovascular and renal actions.
  • ACE2 is increasingly recognized as a potential biomarker in kidney disease (KD) and cardiovascular (CV) conditions.
  • Elevated circulating ACE2 activity is observed in patients with cardiovascular disease, hypertension, and diabetes.

Purpose of the Study:

  • To review the measurement of circulating ACE2.
  • To elucidate the role of ACE2 in kidney disease.
  • To assess the potential of ACE2 as a renal and cardiovascular biomarker.

Main Methods:

  • Review of human and experimental studies on circulating ACE2.
  • Analysis of ACE2 enzymatic activity measurement techniques.
Keywords:
Angiotensin-converting enzyme 2BiomarkerCardiovascular diseaseChronic kidney diseaseReninangiotensin systemdiabetes

Related Experiment Videos

  • Examination of associations between ACE2 and KD, cardiovascular risk factors, and outcomes.

    • Main Results:

    • Circulating ACE2 is increased in patients with cardiovascular disease, hypertension, diabetes, and chronic kidney disease (CKD).
    • ACE2 shows a negative association with estimated glomerular filtration rate in type 1 diabetes patients.
    • In CKD patients, ACE2 is linked to cardiovascular risk factors, atherosclerosis, and adverse CV outcomes.
    • Experimental studies in diabetic nephropathy indicate increased ACE2 activity and urinary albumin excretion.

    Conclusions:

    • Circulating ACE2 levels are altered in various kidney and cardiovascular diseases.
    • ACE2 may serve as a valuable biomarker for renal and cardiovascular risk assessment in KD patients.
    • Further research is warranted to fully understand ACE2's role and clinical utility.