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Juvenile myelomonocytic leukemia with prominent CD141+ myeloid dendritic cell differentiation
Howard Meyerson1, Amad Awadallah1, Georgetta Blidaru1
1Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH 44106.
Human Pathology
|April 18, 2017
Abstract:
Myeloid malignancies showing CD141+ myeloid dendritic cell (MDC) differentiation have not been documented. Here, we describe a patient with juvenile myelomonocytic leukemia in which a prominent CD141+ cell population was identified most consistent with CD141+ MDCs based on phenotypic similarity with normal CD141+ MDCs. Molecular studies demonstrated a KRAS mutation. The findings from the spleen and bone marrow are described. This is the first well-documented demonstration of CD141+ MDC differentiation of a hematopoietic neoplasm.