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Innate lymphoid cells and their stromal microenvironments.

Zoltán Kellermayer1, Dóra Vojkovics1, Péter Balogh1

  • 1Department of Immunology and Biotechnology, Szentágothai Research Center, University of Pécs, Hungary; Lymphoid Organogenesis Research Group, Szentágothai Research Center, University of Pécs, Hungary.

Immunology Letters
|April 18, 2017
PubMed
Summary

Stromal cells and innate lymphoid cells (ILCs) are crucial for immune responses. This review explores their tissue-specific interactions, particularly focusing on ILC type 3 cells and their microenvironment.

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Auxiliary cells, including stromal cells and innate lymphoid cells (ILCs), significantly impact immune responses against pathogens.
  • Stromal cells maintain lymphoid tissue microenvironments, while ILCs are lymphoid cells generated independently of antigen receptors.

Purpose of the Study:

  • To review the main features and interactions between lymphoid stromal cells and innate lymphoid cells.
  • To highlight the tissue-specific collaboration between these cell types, with a focus on ILC type 3 cells.

Main Methods:

  • Literature review of recent studies on stromal cells and ILCs.
  • Analysis of ILC generation and function.
  • Examination of tissue-specific immune responses and microenvironmental influences.
Keywords:
DevelopmentEpitheliumInnate lymphoid cellsLymphoid tissueStroma

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Main Results:

  • Stromal cells are essential for creating and maintaining lymphoid tissue microenvironments.
  • Innate lymphoid cells contribute to inflammation and pathogen protection in a tissue-specific manner.
  • Evidence suggests potential tissue-specific collaboration between stromal cells and ILCs.

Conclusions:

  • Lymphoid stromal cells and ILCs play critical, tissue-specific roles in immunity.
  • Understanding their interactions, especially ILC type 3 cells with their microenvironment, is vital for immune response regulation.