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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Related Experiment Video

Updated: May 2, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
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Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

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Supramolecular Photoactivatable Anticancer Hydrogels.

V Venkatesh1, Narendra Kumar Mishra2, Isolda Romero-Canelón1

  • 1Department of Chemistry, University of Warwick , Gibbet Hill Road, Coventry CV4 7AL, United Kingdom.

Journal of the American Chemical Society
|April 18, 2017
PubMed
Summary
This summary is machine-generated.

New platinum(IV) anticancer drug conjugates (Pt-DA) were embedded in G-quadruplex hydrogels. The resulting Pt-G4K+B hydrogels show enhanced photocytotoxicity against ovarian cancer cells.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Oncology

Background:

  • Platinum(IV) complexes offer potential in cancer therapy.
  • G-quadruplex structures and hydrogels are explored for drug delivery.
  • Photoactivatable drugs enhance targeted cancer treatment.

Purpose of the Study:

  • To develop a photoactivatable platinum(IV) anticancer complex conjugated to G-quadruplex hydrogels.
  • To investigate the photocytotoxicity and selectivity of the novel hydrogel system.

Main Methods:

  • Synthesis and characterization of a photoactivatable dopamine-conjugated platinum(IV) complex (Pt-DA).
  • Incorporation of Pt-DA into G-quadruplex G4K+ borate hydrogels (Pt-G4K+B hydrogel) via borate ester linkages.
  • Evaluation of photocytotoxicity against cisplatin-resistant ovarian cancer cells and normal fibroblast cells using blue light irradiation.

Main Results:

  • Microscopy confirmed structural changes in the hydrogel upon Pt-DA incorporation.
  • Pt-DA exhibited photocytotoxicity against A2780Cis cells (IC50 74 μM).
  • Pt-G4K+B hydrogels demonstrated significantly enhanced photocytotoxicity (IC50 3 μM) with a higher photocytotoxic index (>5).
  • Both Pt-DA and Pt-G4K+B hydrogels showed selective toxicity towards cancer cells over normal fibroblast cells.

Conclusions:

  • The developed Pt-G4K+B hydrogels represent a promising platform for targeted photochemotherapy.
  • The hydrogel formulation enhances the potency and selectivity of the photoactivatable platinum complex.
  • This approach offers potential for improved treatment of cisplatin-resistant ovarian cancers.