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2-dimensional shear wave elastography: Interobserver agreement and factors related to interobserver discrepancy.
Kibo Yoon1, Woo Kyoung Jeong2, Yongsoo Kim1
1Department of Radiology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Gyeonggi-do, Korea.
Plos One
|April 18, 2017
Summary
Interobserver reproducibility of two-dimensional shear wave elastography (2D-SWE) for liver stiffness (LS) measurement was good. The mean standard deviation (SDM) was the most significant factor associated with interobserver differences in LS.
Area of Science:
- Medical Imaging
- Hepatology
- Rheumatology
Background:
- Rheumatoid arthritis patients treated with methotrexate often require liver stiffness monitoring.
- Two-dimensional shear wave elastography (2D-SWE) is a non-invasive method for assessing liver stiffness (LS).
- Evaluating the interobserver reproducibility of 2D-SWE is crucial for its clinical application.
Purpose of the Study:
- To assess the interobserver reproducibility of 2D-SWE in measuring liver stiffness.
- To identify factors influencing interobserver variability in 2D-SWE measurements of liver stiffness.
Main Methods:
- A prospective study involving 176 rheumatoid arthritis patients treated with methotrexate.
- Interobserver reproducibility of 2D-SWE was evaluated.
- Linear regression analyses identified factors associated with interobserver differences in LS, including clinical and investigation factors.
Main Results:
- The intraclass correlation coefficient for interobserver reproducibility was 0.784.
- Mean standard deviation (SDM) and region of interest mean diameter (ROIM) were significantly associated with interobserver differences in LS in multivariate analysis.
- An SDM cut-off value of 1.4 best predicted interobserver discrepancy in LS-based fibrosis staging.
Conclusions:
- 2D-SWE demonstrates good interobserver reproducibility for measuring liver stiffness.
- SDM emerged as the most significant factor related to interobserver differences in LS and fibrosis staging discordance.