Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Triangles bridge the scales: Quantifying cellular contributions to tissue deformation.

Matthias Merkel1,2, Raphaël Etournay3,4, Marko Popović1

  • 1Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Str. 8, 01187 Dresden, Germany.

Physical Review. E
|April 19, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patterns of appointment cancellations and no-shows across and within ophthalmology subspecialties.

Eye (London, England)·2026
Same author

Fluid Flow and Spatiotemporal Chaos in Chemically Active Emulsions.

Physical review letters·2026
Same author

Post-Marketing Ocular Adverse Events Associated with Tamoxifen and Raloxifene: A Population-Based Pharmacovigilance Study.

Retina (Philadelphia, Pa.)·2026
Same author

The Procedure-Only Transfer Pathway - An Alternative to Standard Interhospital Transfer to Address Time-Sensitive Procedural Needs.

NEJM catalyst innovations in care delivery·2026
Same author

A model of 3D confluent tissue behaves as an under-constrained glass.

Soft matter·2026
Same author

Advancing mechanobiology from single molecules to complex cellular systems.

Nature nanotechnology·2026

This study introduces a triangle-based framework to analyze cellular network dynamics and topology in 2D tissues. The method precisely decomposes large-scale tissue deformation, revealing insights into morphogenesis and tissue remodeling.

Area of Science:

  • Developmental Biology
  • Biophysics
  • Cellular Dynamics

Background:

  • Epithelial tissues undergo significant deformation during organism development (morphogenesis).
  • These large-scale deformations arise from numerous individual cellular events.
  • Understanding the collective behavior of cells is crucial for tissue development.

Purpose of the Study:

  • To propose a general framework for studying the dynamics and topology of cellular networks in 2D tissues.
  • To provide an exact decomposition of large-scale material deformation in cell packings.
  • To investigate the contributions of cellular behaviors to tissue deformation.

Main Methods:

  • Development of a triangle-based representation for cellular network geometry.
  • Analysis of cellular events including shape changes, rearrangements, divisions, and extrusions.

Related Experiment Videos

  • Application of the framework to study tissue remodeling in Drosophila melanogaster pupal wings.

    • Main Results:

    • An exact decomposition of large-scale material deformation was achieved.
    • Correlations between cellular rotations and elongation contribute to tissue deformation.
    • Cellular growth and elongation also significantly impact tissue deformation.

    Conclusions:

    • The triangle-based framework offers a precise method to analyze tissue deformation.
    • The study highlights the importance of correlated cellular behaviors in morphogenesis.
    • This approach provides valuable insights into tissue remodeling processes.