Related Experiment Video
Updated: Jan 19, 2026

Time-Resolved Fluorescence Anisotropy from Single Molecules for Characterizing Local Flexibility in Biomolecules
Published on: April 25, 2025
Simple bounds on fluctuations and uncertainty relations for first-passage times of counting observables
1School of Physics and Astronomy and Centre for the Mathematics and Theoretical Physics of Quantum Non-equilibrium Systems, University of Nottingham, Nottingham NG7 2RD, United Kingdom.
Abstract:
Recent large deviation results have provided general lower bounds for the fluctuations of time-integrated currents in the steady state of stochastic systems. A corollary are so-called thermodynamic uncertainty relations connecting precision of estimation to average dissipation. Here we consider this problem but for counting observables, i.e., trajectory observables which, in contrast to currents, are non-negative and nondecreasing in time (and possibly symmetric under time reversal). In the steady state, their fluctuations to all orders are bound from below by a Conway-Maxwell-Poisson distribution dependent only on the averages of the observable and of the dynamical activity. We show how to obtain the corresponding bounds for first-passage times (times when a certain value of the counting variable is first reached) and their uncertainty relations. Just like entropy production does for currents, dynamical activity controls the bounds on fluctuations of counting observables.
More Related Videos
Related Concept Videos
Limits with Oscillating Discontinuities
The Uncertainty Principle
Propagation of Uncertainty from Random Error
Propagation of Uncertainty from Systematic Error
BIBO stability of continuous and discrete -time systems
To determine the BIBO stability, the convolution integral is utilized when a bounded continuous-time input is applied to a Linear Time-Invariant (LTI) system....
Uncertainty: Confidence Intervals

