Drug kinetics release from Eudragit - Tenofovir@SiOC tablets.

Area of Science:

• Materials Science
• Drug Delivery Systems
• Biomedical Engineering

Background:

• Developing advanced drug delivery systems is crucial for sustained therapeutic efficacy.
• Porous silicon oxycarbide (SiOC) glasses offer unique properties for drug loading and release.
• Tenofovir is a key antiviral medication requiring effective delivery strategies.

Purpose of the Study:

• To develop and characterize a novel drug release system for tenofovir using porous SiOC.
• To investigate the adsorption kinetics and in vitro release profiles of tenofovir from SiOC-based systems.
• To compare the performance of functionalized SiOC with other porous materials like active carbon and mesoporous silica.

Main Methods:

• Fabrication of tenofovir-loaded porous SiOC glasses, functionalized with amine groups.
• Adsorption studies using pseudo-second order kinetics and Langmuir isotherm models.
• In vitro drug release testing in a simulated vaginal medium over an extended period (>20 days).
• Analysis of drug release mechanisms, including diffusion and polymer swelling.

Main Results:

• Porous SiOC exhibited a stable bimodal mesopore size distribution after amine functionalization.
• Pseudo-second order kinetics and Langmuir isotherm accurately modeled tenofovir adsorption, indicating a favorable process.
• Amine-functionalized SiOC demonstrated continuous tenofovir release exceeding 20 days in vitro.
• Drug release was characterized by a two-step process involving pore diffusion and polymer swelling.

Conclusions:

• Amine-functionalized porous SiOC glasses are effective carriers for sustained tenofovir release.
• The drug release mechanism involves diffusion through SiOC pores and a swollen polymer layer, influenced by drug-amine interactions.
• This novel SiOC-based system shows significant potential for long-term vaginal drug delivery applications.