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Published on: August 20, 2014
Characterization of the surface physico-chemistry of plasticized PVC used in blood bag and infusion tubing
H Al Salloum1, J Saunier1, A Dazzi2
1IFR 141, EA 401, UFR de Pharmacie, Univ. Paris Sud - Université Paris-Saclay, 92290 Chatenay Malabry, France.
Abstract:
Commercial infusion tubing and blood storage devices (tubing, blood and platelets bags) made of plasticized PVC were analyzed by spectroscopic, chromatographic and microscopic techniques in order to identify and quantify the additives added to the polymer (lubricants, thermal stabilizers, plasticizers) and to put into evidence their blooming onto the surface of the devices. For all the samples, deposits were observed on the surface but with different kinds of morphologies. Ethylene bis amide lubricant and metallic stearate stabilizers were implicated in the formation of these layers. In contact with aqueous media, these insoluble deposits were damaged, suggesting a possible particulate contamination of the infused solutions.

