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In vitro evaluation of osteoblastic cells on bacterial cellulose modified with multi-walled carbon nanotubes as
José Manuel Gutiérrez-Hernández1, Diana María Escobar-García2, Alfredo Escalante3
1Coordination for Innovation and Application of Science and Technology, Autonomous University San Luis Potosi, 78000 San Luis Potosi, Mexico; Department of Wood, Cellulose and Paper Research, University Guadalajara, 45110 Guadalajara, Mexico.
Abstract:
In this paper we explore the use of native bacterial cellulose (BC) in combination with functionalized multi-walled carbon nanotubes (MWNTs) as an original biomaterial, suitable three-dimensional (3D) scaffold for osteoblastic cell culture. Functionalized MWNTs were mixed with native BC (secreted by Gluconacetobacter xylinus) with the aim of reinforcing the mechanical properties of BC. The results indicate that BC-MWNTs scaffolds support osteoblast viability, adhesion and proliferation at higher levels as compared to traditional culture substrates. Chemically functionalized MWNTs are also an excellent material to be used as scaffold because these did not affect cell viability and showed an enhanced osteoblast adhesion. These results suggest the potential for this combination of biomaterials, i.e. BC and carbon nanomaterials, as scaffolds for bone regeneration.