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An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
Published on: June 7, 2015
Design of Salecan-containing semi-IPN hydrogel for amoxicillin delivery
Xiaoliang Qi1, Wei Wei1, Junjian Li1
1Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing 210094, China.
Abstract:
Salecan is a new linear extracellular β-glucan. The unique structure and beneficial properties of Salecan makes it an appealing material in biomedical applications. In this work, novel drug devices based on Salecan in a hydrogel matrix of poly(N-(3-dimethylaminopropyl)acrylamide-co-acrylamide) (Salecan/PDA) were fabricated via free radical polymerization for controlled release of amoxicillin. It was demonstrated that amoxicillin was efficiently encapsulated into the developed hydrogels and released in a Salecan dose-dependent and pH-sensitive manner. Furthermore, cell toxicity and adhesion assays confirmed that these drug carriers were biocompatible. Altogether, this study opens a new avenue to fabricate hydrogel devices for controlled delivery of drug.
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