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Highly selective thiocyanate optochemical sensor based on manganese(III)-salophen ionophore
Fatehy M Abdel-Haleem1, Mahmoud S Rizk1
1Chemistry department, Faculty of Science, Cairo university, Giza, Egypt.
Summary
A novel optochemical sensor using Mn(III)-salophen ionophore effectively detects thiocyanate in saliva. This sensor offers high selectivity and a micro-molar detection limit, overcoming previous limitations.
Area of Science:
- Analytical Chemistry
- Chemical Sensors
- Materials Science
Background:
- Optochemical sensors offer sensitive detection methods.
- Mn(III)-salophen ionophores are effective complexing agents.
- Accurate thiocyanate detection is crucial for diagnostics.
Purpose of the Study:
- To develop a novel optochemical sensor for thiocyanate detection.
- To enhance selectivity and sensitivity compared to existing sensors.
- To validate the sensor's performance in biological samples.
Main Methods:
- Fabrication of the sensor using Mn(III)-salophen ionophore and ETH7075 chromoionophore in a PVC matrix.
- Investigating the optical response mechanism based on ion extraction and dye protonation.
- Evaluating sensor selectivity, detection limit, response time, and reversibility.
- Testing the sensor for thiocyanate determination in human saliva samples.
Main Results:
- The sensor demonstrated high optical selectivity for thiocyanate over other anions (e.g., perchlorate, salicylate).
- Achieved a micro-molar detection limit with a rapid 2-minute response time at pH 4.5.
- Observed poor reversibility due to strong thiocyanate-ionophore binding, which was addressable.
- Successfully determined thiocyanate in human saliva and spiked saliva samples.
Conclusions:
- The developed Mn(III)-salophen based optochemical sensor provides a selective and sensitive method for thiocyanate detection.
- The sensor shows promise for practical applications in biological fluid analysis.
- Addressing sensor reversibility is key for continuous monitoring applications.