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Simultaneous voltammetric analysis of anti-ulcer and D2-antagonist agents in binary mixture using redox sensor and
Pakinaz Y Khashaba1, Hassan Refat H Ali2, Mohamed M El-Wekil2
1Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Egypt; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Deraya University, El-Minya, Egypt.
Abstract:
Pencil graphite electrode was successfully modified with a thin film of poly (eriochrome black T) and applied for the sensitive and selective voltammetric simultaneous determination of pantoprazole sodium and domperidone in a binary mixture. The preparation and basic electrochemical behavior of poly (eriochrome black T) film on the Pencil graphite electrode were investigated. The modified electrode has exhibited very high electro-catalytic activity towards the cited mixture. The anodic peaks of the both species were well defined with enhanced oxidation peak currents. Under the optimum conditions, the linearity ranges were 0.4-55×10-7M and 0.1-34×10-7M for pantoprazole sodium and domperidone, respectively with detection limits of 0.12×10-7M and 0.04×10-7M for pantoprazole sodium and domperidone, respectively. The proposed sensor has been successfully applied in the analysis of pantoprazole sodium and domperidone in synthetic binary mixtures and human serum.