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Updated: Aug 10, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
Study on montmorillonite/insulin/TiO2 hybrid nanocomposite as a new oral drug-delivery system
Younes Kamari1, Payam Ghiaci2, Mehran Ghiaci1
1Department of Chemistry, Isfahan University of Technology, Isfahan 8415683111, Iran.
Abstract:
This study was conducted in two main stages. In the first stage, drug-loaded montmorillonite nanocomposites were prepared by intercalation of insulin into the montmorillonite layers in acidic deionized (DI) water. In the second stage, to increase the release of insulin from the prepared nanocomposites they were coated with TiO2, an inorganic porous coating, by using titanium (IV) butoxide, as precursor. The prepared nanocomposites were characterized by FT-IR, XRD, FE-SEM, BET, DLS and Zeta potential analysis. After investigating the release behaviour of the nanocomposites by UV-Vis absorbance technique, the results revealed that incorporation of porous TiO2 coating increased the drug entrapment noticeably, and decreased the amount of drug release, so that nanocomposites without and with TiO2 coating released the drug after 60min and 22h in pH7.4, respectively. These results could be used in converting the insulin utilization from injection to oral.
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