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Updated: Aug 11, 2026
08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Long non-coding RNAs in cutaneous melanoma: clinical perspectives
Eva Hulstaert1, Lieve Brochez1, Pieter-Jan Volders2,3,4
1Department of Dermatology, Ghent University Hospital, Ghent, Belgium.
Oncotarget
|April 19, 2017
Summary
Thirteen long non-coding RNA genes (lncRNAs) are identified in skin melanoma development. These lncRNAs may serve as novel biomarkers or therapeutic targets for cutaneous melanoma.
Area of Science:
- Molecular biology
- Oncology
- Genetics
Background:
- Metastatic melanoma has high mortality despite advances in targeted therapy and immunotherapy.
- Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in gene regulation and oncogenesis.
Purpose of the Study:
- To identify and characterize lncRNA genes involved in the pathogenesis of cutaneous melanoma.
- To explore the potential of these lncRNAs as biomarkers or therapeutic targets for melanoma.
Main Methods:
- Bioinformatic analysis and literature review to identify relevant lncRNA genes.
- Analysis of molecular pathways and interactions involving the identified lncRNAs in melanoma pathogenesis.
Main Results:
- Identification of 13 specific lncRNA genes implicated in the development of cutaneous melanoma.
- Elucidation of diverse molecular pathways and interactions through which these lncRNAs exert their effects.
Conclusions:
- The identified lncRNAs play significant roles in the pathogenesis of malignant melanoma.
- These lncRNAs represent promising candidates for future diagnostic biomarkers and therapeutic strategies in melanoma treatment.
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