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A polymorphism at IGF1 locus is associated with anemia.

Maria Adelaide Marini1, Gaia Chiara Mannino2, Teresa Vanessa Fiorentino2

  • 1Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

Oncotarget
|April 19, 2017
PubMed
Summary

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The rs35767 C/T polymorphism near IGF1 influences hemoglobin levels. TT genotype carriers showed higher hemoglobin and a lower risk of anemia compared to C allele carriers.

Area of Science:

  • Genetics
  • Hematology
  • Endocrinology

Background:

  • Insulin-like Growth Factor 1 (IGF-1) is implicated in erythropoiesis.
  • The rs35767 C/T polymorphism near the IGF1 gene correlates with plasma IGF-1 levels.

Purpose of the Study:

  • To investigate the association between the rs35767 C/T polymorphism and hemoglobin concentration and anemia risk.
  • To explore the role of IGF-1 in erythropoiesis homeostasis.

Main Methods:

  • Genotyping of the rs35767 polymorphism using TaqMan allelic discrimination assay in 3286 adult White individuals.
  • Analysis of hemoglobin concentration and anemia prevalence based on genotype.
  • Statistical analysis to assess associations with clinical parameters and adjust for covariates.
Keywords:
Pathology Sectionanemiahemoglobininsulin-like growth factor 1rs35767single nucleotide polymorphism

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Main Results:

  • The rs35767 polymorphism was not associated with numerous metabolic and clinical parameters.
  • TT genotype carriers exhibited significantly higher hemoglobin concentrations compared to C allele carriers.
  • Carriers of the TT genotype had a significantly lower risk of anemia (OR 2.40 for CC, OR 2.06 for CT vs TT).
  • The association between rs35767 and anemia risk remained significant after adjusting for several clinical factors but not for fibrinogen and ESR.

Conclusions:

  • The rs35767 TT allele is associated with higher hemoglobin levels and a reduced risk of anemia.
  • These findings support a role for IGF-1 in erythropoiesis regulation.