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Transdermal oxycodone patch for the treatment of postherpetic neuralgia: a randomized, double-blind, controlled trial
Paul D Gavin1, Louise Tremper1, Alisha Smith1
1Phosphagenics Limited, 11 Duerdin Street, Clayton VIC 3168, Australia.
Aim:
To evaluate the efficacy, systemic exposure, safety and tolerability of a transdermal oxycodone patch containing tocopheryl phosphate mixture (TPM) in patients with postherpetic neuralgia (PHN).
Patients & Methods:
The study was a Phase IIa, multicenter, randomized, double-blind, vehicle-controlled crossover study.
Results:
While the TPM/oxycodone patch did not significantly improve 'average' Numeric Pain Rating Scale scores versus vehicle patch, patients reporting high levels of paresthesia (n = 9) showed a trend toward improved pain reduction. The TPM/oxycodone patch resulted in a low systemic exposure to oxycodone and was well tolerated.
Conclusion:
The TPM/oxycodone patch delivered oxycodone to the site of perceived pain in subjects suffering from PHN, but did not provide analgesia for the broad PHN indication.
