Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic alterations during colorectal-tumor development.

B Vogelstein1, E R Fearon, S R Hamilton

  • 1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD.

The New England Journal of Medicine
|September 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardiac delivery of modified mRNA using lipid nanoparticles: Cellular targets and biodistribution after intramyocardial administration.

Journal of controlled release : official journal of the Controlled Release Society·2024
Same author

Erratum to "Annotated normal CT data of the abdomen for deep learning: Challenges and strategies for implementation" [Diagn. Interv. Imaging. 101 (2020) 35-44].

Diagnostic and interventional imaging·2020
Same author

Differentiating autoimmune pancreatitis from pancreatic ductal adenocarcinoma with CT radiomics features.

Diagnostic and interventional imaging·2020
Same author

Deep lessons learned: Radiology, oncology, pathology, and computer science experts unite around artificial intelligence to strive for earlier pancreatic cancer diagnosis.

Diagnostic and interventional imaging·2019
Same author

Annotated normal CT data of the abdomen for deep learning: Challenges and strategies for implementation.

Diagnostic and interventional imaging·2019
Same author

Circulating tumor DNA as a potential marker of adjuvant chemotherapy benefit following surgery for localized pancreatic cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2019
Same journal

Sparganosis.

The New England journal of medicine·2026
Same journal

Caring for an Aging America - The Looming Crisis of the Long-Term-Care Workforce.

The New England journal of medicine·2026
Same journal

For Those Left Behind.

The New England journal of medicine·2026
Same journal

Colliding Forces - The Aging of the Baby Boom Generation and Contracting Nursing-Home Supply.

The New England journal of medicine·2026
Same journal

Mandated State-Level Surveillance of Assisted Reproductive Technology - An Emerging Threat in the United States.

The New England journal of medicine·2026
Same journal

Ebola at 50 - Lessons for Outbreak Response and Preparedness.

The New England journal of medicine·2026
See all related articles

Genetic alterations like ras-gene mutations and chromosomal deletions accumulate during colorectal tumor progression. These molecular changes, including chromosome 18 deletions, are key to understanding colorectal cancer development from adenomas.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Colorectal carcinomas often develop from adenomas, suggesting a stepwise progression.
  • Understanding genetic alterations in colorectal neoplasia is crucial for tumor progression insights.

Purpose of the Study:

  • To investigate the occurrence and accumulation of four specific genetic alterations in colorectal tumors at various stages.
  • To correlate molecular changes with the clinical progression of colorectal neoplasia.

Main Methods:

  • Analysis of 172 colorectal tumor specimens, including adenomas and carcinomas.
  • Detection of ras-gene mutations and allelic deletions on chromosomes 5, 17, and 18.

Main Results:

  • Ras-gene mutations were more frequent in larger adenomas (>1 cm) and carcinomas than in smaller adenomas.

Related Experiment Videos

  • Allelic deletions on chromosomes 18 and 17p were significantly associated with advanced adenomas and carcinomas.
  • Loss of chromosome 5 sequences occurred in non-familial adenomas and carcinomas, but not in familial adenomatous polyposis-linked adenomas.

    • Conclusions:

    • The accumulation of genetic alterations parallels the clinical progression of colorectal tumors.
    • Colorectal tumorigenesis involves oncogene activation (ras-gene mutations) and loss of tumor suppressor genes (chromosomal deletions).