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History of Depression in Lung Cancer Patients: Impact of Delay
M Iachina1, M M Brønserud2, E Jakobsen2
1Center for Clinical Epidemiology, Odense University Hospital, Odense, Denmark; The Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
Aims:
To examine the influence of a history of depression in the process of diagnostic evaluation and the choice of treatment in lung cancer.
Materials And Methods:
The analysis was based on all patients with non-small cell lung cancer who were registered in 2008-2014; in total, 27 234 patients. To estimate the effect of depression on the diagnostic process and the choice of treatment in lung cancer we fitted a logistic regression model and a Cox regression model adjusting for age, gender, resection and stage.
Results:
Depression in a patient's anamnesis had no significant effect on the delay in diagnostic evaluation (hazard ratio = 0.99 with 95% confidence interval 0.90; 1.09). Patients with a history of periodic depression had a 33% lower treatment rate (odds ratio = 0.66 with 95% confidence interval 0.51; 0.85) than patients without a history of depression.
Conclusions:
Our study shows that patients with a history of periodic depression need special attention when diagnosed with lung cancer.
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