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Related Experiment Videos

HIV infection and aortic stiffness.

Luisa Helena Maia Leite1, Ariel Cohen2, Franck Boccara3

  • 1Department of Infectious Diseases, São Francisco de Assis Hospital, Federal University, Rio de Janeiro, Brazil; Service de Cardiologie, Hôpital Saint-Antoine, AP-HP, Paris, France.

Archives of Cardiovascular Diseases
|April 19, 2017
PubMed
Summary

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People with HIV on antiretroviral therapy have normal life expectancy but higher cardiovascular risk. Studies show mixed results on whether HIV infection accelerates vascular aging, but HIV-related factors impact vascular health.

Area of Science:

  • Cardiovascular Health
  • Infectious Diseases
  • Vascular Aging

Background:

  • Antiretroviral therapy has normalized life expectancy for people with human immunodeficiency virus (HIV).
  • HIV infection is associated with increased risk of atherosclerotic cardiovascular events due to complex vasculopathy.
  • The impact of HIV on vascular aging compared to the general population remains debated.

Purpose of the Study:

  • To review and summarize current research on the association between HIV infection and aortic stiffness.
  • To evaluate HIV's role as a marker of vascular aging.

Main Methods:

  • Systematic review of 18 observational clinical studies published between 2009 and 2016.
  • Studies compared aortic stiffness in HIV-positive (HIV+) and HIV-negative (HIV-) adult populations.
Keywords:
Aortic stiffnessCardiovascular riskHIVPulse wave velocityRigidité aortiqueRisque cardiovasculaireVIHVascular agingVieillissement vasculaireVitesse de l’onde de pouls

Related Experiment Videos

  • Searches conducted on PubMed/MEDLINE and other databases using terms like 'aortic stiffness', 'vascular aging', and 'HIV'.

    • Main Results:

    • Ten of 18 studies (55%) found no significant difference in aortic stiffness between HIV+ and HIV- groups.
    • Key determinants of aortic stiffness included age, blood pressure, smoking, metabolic syndrome, and HIV-specific factors (CD4/CD8 ratio, CD4 counts).
    • Results on increased aortic stiffness in HIV+ individuals were discordant, but HIV-related conditions consistently showed an association with vascular health.

    Conclusions:

    • Evidence is conflicting regarding whether HIV+ individuals exhibit increased aortic stiffness.
    • HIV-related conditions and immune activity appear to influence vascular health and large arteries.
    • Further research is needed to fully understand the link between HIV and accelerated vascular aging.