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Analysis of methylation of a human X located gene which escapes X inactivation
C Mondello1, P J Goodfellow, P N Goodfellow
1Istituto di Genetica Biochimica ed Evoluzionistica del CNR, Pavia, Italy.
Nucleic Acids Research
|July 25, 1988
Abstract:
The gene MIC2 is located in the pseudoautosomal region at the ends of the short arms of the X and Y chromosomes. In females MIC2 escapes X inactivation. We have analyzed the methylation pattern of MIC2 on the active X, the inactive X chromosomes, and the Y chromosome. The 5' end of the gene contains a GC rich region which is unmethylated on the active X, the inactive X and on the Y. The body of the gene is characterized by variable methylation.