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Stardust, the Janus-faced partner of Crumbs
Shradha Das1, Elisabeth Knust2
1Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
The Journal of Cell Biology
|April 19, 2017
Abstract:
The Drosophila melanogaster scaffolding protein Stardust (Sdt) stabilizes the transmembrane protein Crumbs, a conserved regulator of apical-basal epithelial polarity. In this issue, Perez-Mockus et al. (2017. J. Cell Biol https://doi.org/10.1083/jcb.201611196) report that a subset of Sdt isoforms are targeted by the ubiquitin ligase Neuralized, thus fine tuning the endocytosis and activity of this apical determinant.