Performance Stability of Silicone Oxide-Coated Plastic Parenteral Vials

Area of Science:

• Materials Science
• Pharmaceutical Packaging
• Coating Technology

Background:

• Traditional glass parenteral packaging faces challenges like delamination and breakage.
• Expanding pharmaceutical markets and regulatory demands necessitate improved packaging solutions.
• Product recalls highlight the risks associated with conventional glass containers for injectables.

Purpose of the Study:

• To develop an advanced packaging system for parenteral pharmaceuticals.
• To combine the advantages of plastic and glass while mitigating their respective drawbacks.
• To create a packaging solution that enhances product stability and safety.

Main Methods:

• Utilizing high-precision injection-molded plastics.
• Applying plasma coating technology to create a multilayer composite.
• Engineering a glass-coated plastic material for pharmaceutical containment.

Main Results:

• The new system is shatter-resistant, optically clear, and low-particulate.
• It demonstrates superior chemical durability compared to traditional materials.
• The packaging meets or exceeds glass performance, preventing delamination and breakage.
• It provides a chemically stable contact surface and oxygen barrier exceeding 2-year shelf life.

Conclusions:

• The developed packaging system offers a significant advancement for parenteral pharmaceuticals.
• It effectively addresses the limitations of traditional glass packaging.
• This innovative solution ensures enhanced product integrity and extended shelf life.