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Related Experiment Videos

Essential Neuroscience in Immunology.

Sangeeta S Chavan1, Kevin J Tracey2

  • 1Center for Biomedical Science, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY 11030; and Center for Bioelectronic Medicine, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY 11030.

Journal of Immunology (Baltimore, Md. : 1950)
|April 19, 2017
PubMed
Summary

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Neural circuits reflexively regulate immunity, integrating hematopoietic and neural responses. This discovery led to bioelectronic devices for treating rheumatoid arthritis by inhibiting inflammation.

Area of Science:

  • Neuroimmunology
  • Integrative immunology

Background:

  • Traditionally, immunology focused on hematopoietic cells.
  • Recent findings highlight neuronal signals' critical role in regulating immunity.

Purpose of the Study:

  • To review the mechanisms of neural regulation of innate and adaptive immunity.
  • To discuss the implications for understanding immunity and developing new therapies.

Main Methods:

  • Review of existing literature on neuro-immune interactions.
  • Discussion of the inflammatory reflex and other identified neural circuits.
  • Examination of clinical applications and future directions.

Main Results:

  • Neuronal circuits, such as the inflammatory reflex involving the vagus and splenic nerves, are identified as regulators of innate and adaptive immunity.

Related Experiment Videos

  • These discoveries have led to a new understanding of immunity as an integration of hematopoietic and neural responses.
  • A first-in-class clinical trial demonstrated bioelectronic devices' efficacy in inhibiting cytokines and inflammation in rheumatoid arthritis.

    • Conclusions:

    • Immunity is a complex interplay between the hematopoietic and nervous systems.
    • Targeting neural pathways offers novel therapeutic strategies for inflammatory diseases.
    • Bioelectronic medicine represents a promising frontier in treating immune-related conditions.