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Updated: Oct 12, 2026

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Published on: October 12, 2012
Clindamycin-associated acute generalized exanthematous pustulosis
C Croy1, K Buehrle2, J Austin Szwak3
1Department of Pharmacy, Medical University of South Carolina Medical Center, Charleston, SC, USA.
What Is Known And The Objective:
Acute generalized exanthematous pustulosis (AGEP) is a rare, severe cutaneous reaction that usually occurs following medication exposure. Clindamycin has rarely been linked to dermatologic side effects, including AGEP.
Case Summary:
This report details the case of a patient who developed AGEP with vancomycin and clindamycin use. After discontinuing clindamycin, the rash improved significantly.
What Is New And Conclusion:
Timely management of adverse skin reactions to antibiotics is paramount, and early identification of the culprit agent can allow for an alternative agent to be utilized. Clindamycin should be considered a potential causative agent for patients with skin reactions.
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