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Related Experiment Videos

Thrombin-antithrombin III complex tests.

Sang Yang Lee1, Takahiro Niikura1, Takashi Iwakura1

  • 11 Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Journal of Orthopaedic Surgery (Hong Kong)
|April 19, 2017
PubMed
Summary

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Thrombin-antithrombin III complex (TAT) tests on postoperative day 7 show high accuracy in screening for venous thromboembolism (VTE) in patients with pelvic or lower limb fractures. TAT is a reliable tool for VTE screening in this patient group.

Area of Science:

  • Orthopedic Surgery
  • Hematology
  • Diagnostic Medicine

Background:

  • Patients with pelvic or lower extremity fractures face a high risk of developing postoperative venous thromboembolism (VTE).
  • Effective screening methods are crucial for early detection and management of VTE in these vulnerable patients.

Purpose of the Study:

  • To evaluate the efficacy of thrombin-antithrombin III complex (TAT) tests for postoperative VTE screening.
  • To compare the diagnostic performance of TAT with D-dimer in patients with pelvic and lower limb fractures.

Main Methods:

  • A cohort of 133 patients undergoing surgery for pelvic or lower extremity fractures were enrolled.
  • Thrombin-antithrombin III complex (TAT) and D-dimer levels were measured and compared between patients with and without VTE.
Keywords:
deep venous thrombosis (DVT)fracturepulmonary thromboembolism (PTE)thrombin–antithrombin III complex (TAT)venous thromboembolism (VTE)

Related Experiment Videos

  • Receiver operating characteristic (ROC) curve analysis was performed to determine optimal cutoff levels for VTE screening.

    • Main Results:

    • Venous thromboembolism (VTE) was diagnosed in 30.8% of the patients.
    • Significantly elevated TAT and D-dimer levels were observed in patients with VTE on postoperative days 1, 3, and 7.
    • The TAT test on postoperative day 7 demonstrated the highest accuracy, with a sensitivity of 93.3% and specificity of 70.1% at a cutoff of 3.0 ng/mL.

    Conclusions:

    • Thrombin-antithrombin III complex (TAT) levels measured on postoperative day 7 are a highly accurate parameter for screening postoperative VTE.
    • The TAT test serves as a valuable screening tool for identifying VTE in patients with lower limb and pelvic fractures.