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Related Experiment Videos

The human papillomaviruses. An overview.

P M Howley1, R Schlegel

  • 1Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, Maryland 20892.

The American Journal of Medicine
|August 29, 1988
PubMed
Summary

Human papillomaviruses (HPVs) are linked to precancerous and cancerous lesions. Understanding HPV infection

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Area of Science:

  • Virology
  • Oncology
  • Dermatology

Background:

  • Papillomaviruses, including over 50 types of human papillomaviruses (HPVs), are small DNA viruses implicated in proliferative squamous epithelial lesions across various vertebrates.
  • Certain HPV types are associated with benign genital lesions, some considered precancerous, and their DNA is frequently detected in cervical, penile, and vulvar cancers.
  • The etiologic role of specific HPVs in these malignancies is supported by their consistent presence in cancerous tissues.

Purpose of the Study:

  • To explore the biology and natural history of human papillomavirus (HPV) infections.
  • To investigate the factors influencing the clinical manifestation of HPV infections.
  • To understand the host's cellular and humoral immune responses to HPV infections and their role in disease resolution.

Main Methods:

  • Review of existing literature on papillomavirus and human papillomavirus (HPV) infections.
  • Analysis of clinical observations regarding HPV-associated lesions and malignancies.
  • Examination of the persistence of HPV DNA in clinically normal tissues.

Main Results:

  • Over 50 distinct human papillomaviruses (HPVs) are recognized, each linked to specific clinical lesions.
  • HPVs are associated with benign proliferative lesions, precancerous conditions, and cancers of the genital tract.
  • HPV DNA can persist latently in apparently normal tissues, indicating complex infection dynamics.

Conclusions:

  • The etiologic role of specific HPVs in cervical, penile, and vulvar cancers is strongly suggested.
  • The biology and natural history of HPV infections remain poorly understood, with unknown influencing factors.
  • Host immune responses are likely critical for resolving HPV-associated diseases, though information is limited.

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